生物
母子转换
诱导多能干细胞
胚胎干细胞
全能的
细胞生物学
胚胎
转录组
干细胞
遗传学
胚胎发生
合子
基因表达
基因
作者
Jasmin Taubenschmid-Stowers,Wolf Reik
标识
DOI:10.1016/j.gde.2023.102066
摘要
The totipotent embryo initiates transcription during zygotic or embryonic genome activation (EGA, ZGA). ZGA occurs at the 8-cell stage in humans and its failure leads to developmental arrest. Understanding the molecular pathways underlying ZGA and totipotency is essential to comprehend human development. Recently, human 8-cell-like cells (8CLCs) have been discovered in vitro that resemble the 8-cell embryo. 8CLCs exist among naive pluripotent stem cells and can be induced genetically or chemically. Their ZGA-like transcriptome, transposable element activation, 8-cell embryo-specific protein expression, and developmental properties make them an exceptional model system to study early embryonic cell-state transitions and human totipotency programs in vitro.
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