化学
萜类
芳构化
大戟
立体化学
体外
抑制性突触后电位
化学结构
戒指(化学)
萜烯
生物化学
有机化学
传统医学
神经科学
生物
医学
催化作用
作者
Jianyi Huang,Ying Yang,Hong Liu,Xue-Xue Pu,Ying-Yao Li,Min Cai,Feng Guo,Liwu Lin,Mingming Cao,Ying Yan,Yuanyuan Cheng,Ying‐Tong Di,Xiao‐Jiang Hao
标识
DOI:10.1016/j.tetlet.2023.154550
摘要
One new pepluane-type diterpenoid, pepluenone (1), and four known compounds were isolated from the whole plant of Euphorbia peplus L. Compound 1 possesses a 5/6/5/6 tetracyclic skeleton with a unique aromatic ring D. Its structure was determined based on spectroscopic data and X-ray crystallography. The biogenetic pathway of 1 was proposed, in which chemical transformation verified the aromatization step. In vitro anti-inflammatory activity tests indicated that Compounds 1 and 3 had a strong inhibitory effect on releasing NO from mouse macrophage RAW264.7 induced by LPS.
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