[Research progress on proactive healthy lifestyle and disease immunoprevention].

The paradox of increasing health needs and limited health resources prompted a change in the traditional concept of disease prevention and control, and the concept of proactive health has emerged. Proactive health aimed to prevent and control disease and improve the body's immunity by using controlled methods and means to activate the body's self-healing ability and to identify foreign harmful substances as well as damage factors and tumor cells that the body itself may produce while giving full play to individual initiative. With the continuous development of science, people could maintain and improve their immune system from many aspects, which could be roughly divided into nonpharmaceutical interventions and pharmaceutical interventions. Nonpharmacological interventions included changing lifestyles and habits, adjusting the nutritional structure and intake of food, regulating mindsets and emotions, and improving the living and working environment, etc. This review systematically elaborated on the functions and molecular mechanisms of nutrition, exercise, sleep, and emotion in regulating immunity, to provide some scientific evidence and theoretical support for proactive health.随着人们对健康需求的增加和卫生资源有限的矛盾促使传统疾病防控理念的改变，主动健康理念应时而生。主动健康的任务是在充分发挥个体能动性的前提下，综合利用可控的方法手段，激活机体自愈能力，识别外来有害物质以及人体本身可能产生的损伤因子和肿瘤细胞等，达到防治疾病和提高机体免疫的目的。随着科学不断发展，人们可以从很多方面维护和“修理”自己的免疫系统，大致分为非药物干预方式和药物干预方式。非药物干预方式比如改变生活方式和习惯、调整食物营养结构和摄入量、调整心态情绪、改善生活和工作环境等。本综述将系统阐述营养、运动、睡眠及情绪四大主动健康生活方式在调节机体免疫方面的功能和分子机制，旨在为主动健康提供一些科学证据和理论支持。.