ATP合酶
ATP水解
生物
线粒体
三磷酸腺苷
生物化学
粒线体疾病
化学渗透
功能(生物学)
酶
细胞生物学
线粒体DNA
ATP酶
基因
作者
Gabriel E. Valdebenito,Anitta R. Chacko,Michael R. Duchen
标识
DOI:10.15252/embj.2023114141
摘要
The mitochondrial F 1 F o ‐ATP synthase uses a rotary mechanism to synthesise ATP. This mechanism can, however, also operate in reverse, pumping protons at the expense of ATP, with significant potential implications for mitochondrial and age‐related diseases. In a recent study, Acin‐Perez et al (2023) use an elegant assay to screen compounds for the capacity to selectively inhibit ATP hydrolysis without affecting ATP synthesis. They show that (+)‐epicatechin is one such compound and has significant benefits for cell and tissue function in disease models. These findings signpost a novel therapeutic approach for mitochondrial disease.
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