Crosslinked albumin–manganese nanoaggregates with sensitized T1 relaxivity and indocyanine green loading for multimodal imaging and cancer phototherapy

An aggregation and crosslinking strategy is proposed for constructing high-relaxivity C-BM. The further increased r 1 , stabler FL, stronger PA and better PT effect are achieved in C-BM/I, which can be used for MR, NIR-II FL and PA imaging and PTT-PDT.