Glioblastoma Multiforme: The Role of Hypoxic Microenvironments in Glioblastoma Multiforme Tumors

Glioblastoma Multiforme (GBM) is a high-grade glioma and one of the most aggressive tumor types within the central nervous system. Extensive research has explored the role of the tumor microenvironment in GBM progression, revealing diverse interactions and pathways that drive its development. A significant focus has been on hypoxic microenvironments, which are common in GBM and contribute to its immunosuppressive nature. The high heterogeneity and immunosuppressive characteristics of GBM present challenges for treatment, often reducing the efficacy of traditional therapies like chemotherapy and radiation. As a result, there is increasing interest in combination therapies as a more effective strategy for managing this aggressive cancer. This paper focuses on exploring research conducted on understanding the role hypoxic microenvironments play in GBMs persistence.