Trajectories of Symptom Clusters and Their Predictive Factors in Patients With Colorectal Cancer 3 Months After Surgery: A Longitudinal Study

医学 焦虑 萧条(经济学) 生活质量(医疗保健) 结直肠癌 逻辑回归 心情 内科学 纵向研究 观察研究 前瞻性队列研究 围手术期 癌症 物理疗法 外科 精神科 宏观经济学 病理 护理部 经济
作者
Yue Li,Wenwen Gan,Qin Mao,Hongying Wu,Ting Cao,Haiyan Wu,Xiaorong Mao
出处
期刊:Cancer Medicine [Wiley]
卷期号:14 (13): e71025-e71025
标识
DOI:10.1002/cam4.71025
摘要

ABSTRACT Aims To examine the changing trajectories of symptom clusters within 3 months following surgery in patients with colorectal cancer (CRC) and identify their predictive factors. Design A prospective longitudinal observational study. Methods Convenience sampling was used to recruit inpatients with CRC who were scheduled for surgical treatment at the Sichuan Provincial People's Hospital between October 2022 and September 2023. The Chinese version of the MD Anderson Symptom Inventory Gastrointestinal Cancer Module was utilized. The prevalence and severity of patients' symptoms were assessed at 7 days (T1), 6 weeks (T2), and 3 months (T3). Before the operation, a total of 240 patients with CRC were recruited. There were 203, 164, and 139 patients participating in T1, T2, and T3, respectively. Exploratory factor analysis identified symptom clusters. Latent class growth modeling determined the developmental trajectories of symptom clusters, and binomial logistic regression analyzed predictors of trajectory classification. Results Two clinical subgroups were identified: a “high symptom—decreases and then increases” (17.2%) and a “low symptoms—continuous decline” (82.8%). The latter exhibited significantly lower and progressively declining symptom severity compared to the former. Predictive factors for the “high symptom—decreases and then increases” subgroup included multimorbidity (≥ 2 chronic conditions), chronic lung disease, preoperative frailty, severe anxiety/depression, open surgery, and postoperative chemotherapy. Conclusions Targeted management of the mood‐sleep disorder cluster (T1) and the activity intolerance cluster (T2/T3) may significantly improve patients' quality of life. The “high symptom—decreases then increases” subgroup warrants prioritized clinical attention, as early intervention for its predictive factors (e.g., frailty, anxiety, and depression) could enhance postoperative outcomes. Integrating these factors into routine preoperative assessments is recommended.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
进化又不带我完成签到 ,获得积分10
刚刚
WWWUBING完成签到,获得积分10
1秒前
星辰大海应助snowman采纳,获得10
1秒前
盛志孟发布了新的文献求助10
2秒前
蓝调子发布了新的文献求助30
2秒前
奈何发布了新的文献求助10
2秒前
abocide发布了新的文献求助10
3秒前
顺利毕业完成签到 ,获得积分10
3秒前
古叶完成签到,获得积分10
5秒前
Zhang发布了新的文献求助10
5秒前
赘婿应助盛志孟采纳,获得10
5秒前
5秒前
5秒前
6秒前
7秒前
青柠发布了新的文献求助10
8秒前
KKUMee完成签到,获得积分10
8秒前
8秒前
10秒前
Orange应助海棠采纳,获得10
10秒前
CipherSage应助勤劳半青采纳,获得10
12秒前
12秒前
蜡笔小哐发布了新的文献求助10
13秒前
秋水百合发布了新的文献求助10
13秒前
YU发布了新的文献求助10
14秒前
14秒前
跳跃靖应助一茗采纳,获得10
15秒前
清茶旧友完成签到,获得积分10
15秒前
JamesPei应助洛水采纳,获得10
16秒前
16秒前
科研通AI6.2应助蓝调子采纳,获得10
17秒前
18秒前
想飞的猪完成签到,获得积分10
18秒前
XU2025完成签到 ,获得积分10
18秒前
19秒前
19秒前
情怀应助掌上三寸采纳,获得10
21秒前
不潮薯饼举报星之宇痕求助涉嫌违规
21秒前
22秒前
23秒前
高分求助中
(应助此贴封号)【重要!!请各用户(尤其是新用户)详细阅读】【科研通的精品贴汇总】 10000
2026年中国辛酸癸酸聚乙二醇甘油酯行业市场现状调查及投资机会研判报告 1000
2026年中国辛酸癸酸聚乙二醇甘油酯行业市场规模及竞争格局分析报告 1000
48V Low-voltage Power Distribution Network (PDN) Architecture Industry Report, 2024 800
Fundamentals of Pharmaceutical and Biologics Regulations: A Global Perspective, Second Edition 700
Resiliency Scale for Adolescents--Chinese Version 600
Matrix Methods in Data Mining and Pattern Recognition Second Edition 510
热门求助领域 (近24小时)
化学 材料科学 医学 生物 纳米技术 工程类 有机化学 化学工程 生物化学 计算机科学 内科学 物理 复合材料 催化作用 细胞生物学 无机化学 光电子学 物理化学 电极 基因
热门帖子
关注 科研通微信公众号,转发送积分 7319810
求助须知:如何正确求助?哪些是违规求助? 8935503
关于积分的说明 18942493
捐赠科研通 6978363
什么是DOI,文献DOI怎么找? 3214413
关于科研通互助平台的介绍 2382293
邀请新用户注册赠送积分活动 2193474