Nickel-catalyzed multicomponent 1,4-fluoroalkylcarbonylation of 1,3-enynes to access allenyl ketones

Allenyl ketones are widely distributed in various bioactive molecules which lead their selective synthesis continues a hot research topic. Currently, most of the developed protocols require multistep and stoichiometric reactions together with noble metal catalysts. Herein, we developed a practical methodology to access allenyl ketones straightforwardly via multi-component coupling of 1,3-enynes, fluoroalkyl halides, arylboronic acids, and CO with nickel as the catalyst. A series of fluoroalkyl unit containing allenyl ketones were produced in moderate to good yields. This new procedure features cheap catalytic system, relatively mild reaction conditions, broad substrate scope, excellent regioselectivity, and attractive synthetic transformations of the obtained products.