血管生成
伤口愈合
自愈水凝胶
钙
体内
缺氧(环境)
药理学
细胞外基质
氧气
生物医学工程
化学
医学
外科
癌症研究
生物化学
生物
生物技术
有机化学
作者
Na Li,Xiaohuan Lu,Yueying Yang,Shan Ning,Yuan Tian,Mengyuan Zhou,Zheng Wang,Lin Wang,Jianfeng Zang
标识
DOI:10.1002/adhm.202303314
摘要
Abstract Nonhealing diabetic wounds are predominantly attributed to the inhibition of angiogenesis, re‐epithelialization, and extracellular matrix (ECM) synthesis caused by hypoxia. Although oxygen therapy has demonstrated efficacy in promoting healing, its therapeutic impact remains suboptimal due to unsustainable oxygenation. Here, this work proposes an oxygen‐releasing hydrogel patch embedded with polyethylene glycol‐modified calcium peroxide microparticles, which sustainably releases oxygen for 7 days without requiring any supplementary conditions. The released oxygen effectively promotes cell migration and angiogenesis under hypoxic conditions as validated in vitro. The in vivo tests in diabetic mice models show that the sustainably released oxygen significantly facilitates the synthesis of ECM, induces angiogenesis, and decreases the expression of inflammatory cytokines, achieving a diabetic wound healing rate of 84.2% on day 7, outperforming the existing oxygen‐releasing approaches. Moreover, the proposed hydrogel patch is designed with porous, soft, antibacterial, biodegradable, and storage stability for 15 days. The proposed hydrogel patch is expected to be promising in clinics treating diabetic wounds.
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