The expression of circSATB2, PEAK1 in non-small cell lung cancer tissue and their relationships with clinical pathological characteristics, as well as postoperative recurrence and metastasis

We studied the circSATB2 and PEAK1 expression in NSCLC tissues and their associations with clinicopathological features, recurrence, and metastasis. Tumor and adjacent tissues from 98 NSCLC patients (2019-2020) were analyzed using qPCR (circSATB2) and immunohistochemistry (PEAK1). Pearson correlation assessed circSATB2-PEAK1 mRNA relationships. Survival analysis compared high/low expression groups. Cox regression identified risk factors for recurrence/metastasis. circSATB2 and PEAK1 mRNA were upregulated in NSCLC tissues, correlating with lymph node metastasis and advanced TNM stage (IIIa). circSATB2 positively correlated with PEAK1 mRNA. High expression of both predicted poorer survival (Kaplan-Meier). Multivariate analysis identified high circSATB2, high PEAK1, lymph node metastasis, and stage IIIA as independent risk factors for postoperative recurrence/metastasis. In conclusion, elevated circSATB2 and PEAK1 in NSCLC are linked to aggressive clinicopathological features and poor prognosis, serving as biomarkers for recurrence/metastasis risk.