Recent advances of chiral metal-organic frameworks in analytic chemistry

Analytical chemistry plays an irreplaceable role in the fields of energy, agriculture, medicine, chemical industry, environmental protection, and so on. Thanks to the blooming prosperity of chiral science, the development of novel and efficient analytical probes toward chiral substances is also becoming the research frontier in modern analytical chemistry. Chiral metal-organic frameworks (CMOFs) enjoy their high surface areas, regulable framework structures, accessible chiral sites, specific substrate interaction, and beyond, which enable them as potential platforms for versatile analytical applications. In this review, the recent advances in applications of CMOFs in chiral sensing, enantioselective detection, chiral chromatographic separation, and bioimaging are comprehensively surveyed and introduced. Current challenges and future research outlooks in this filed are also discussed and prospected. This review is hoped to be instructive for researchers in the development of high-performance CMOFs used in analytical chemistry.