记忆巩固
突触可塑性
变质塑性
神经科学
海马结构
长时程增强
神经可塑性
生物
海马体
心理学
生物化学
受体
作者
Vidya Sharma,Mauricio M. Oliveira,Rapita Sood,Abdessattar Khlaifia,Danning Lou,Mehdi Hooshmandi,Tzu-Yu Hung,Niaz Mahmood,Mariclair A. Reeves,David Ho-Tieng,Noah Cohen,Po-chieh Cheng,Mir Munir A. Rahim,Masha Prager‐Khoutorsky,Randal J. Kaufman,Kobi Rosenblum,Jean-Claude Lacaille,Arkady Khoutorsky,Eric Klann,Nahum Sonenberg
标识
DOI:10.1073/pnas.2308671120
摘要
Activation of neuronal protein synthesis upon learning is critical for the formation of long-term memory. Here, we report that learning in the contextual fear conditioning paradigm engenders a decrease in eIF2α (eukaryotic translation initiation factor 2) phosphorylation in astrocytes in the hippocampal CA1 region, which promotes protein synthesis. Genetic reduction of eIF2α phosphorylation in hippocampal astrocytes enhanced contextual and spatial memory and lowered the threshold for the induction of long-lasting plasticity by modulating synaptic transmission. Thus, learning-induced dephosphorylation of eIF2α in astrocytes bolsters hippocampal synaptic plasticity and consolidation of long-term memories.
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