Notch信号通路
细胞生物学
信号转导
Hes3信号轴
线粒体
效应器
氧化磷酸化
细胞信号
细胞代谢
细胞内
生物
新陈代谢
生物化学
作者
Qi Shen,Yunsheng Yuan,Jinlan Jin
出处
期刊:PubMed
日期:2023-12-01
卷期号:35 (12): 1321-1326
标识
DOI:10.3760/cma.j.cn121430-20230719-00532
摘要
Notch signaling pathway is a highly conserved signaling pathway in the process of evolution. It is composed of three parts: Notch receptor, ligand and effector molecules responsible for intracellular signal transduction. It plays an important role in cell proliferation, differentiation, development, migration, apoptosis and other processes, and has a regulatory effect on tissue homeostasis and homeostasis. Mitochondria are the sites of oxidative metabolism in eukaryotes, where sugars, fats and proteins are finally oxidized to release energy. In recent years, the regulation of Notch signaling pathway on mitochondrial energy metabolism has attracted more and more attention. A large number of data have shown that Notch signaling pathway has a significant effect on mitochondrial energy metabolism, but the relationship between Notch signaling pathway and mitochondrial energy metabolism needs to be specifically and systematically discussed. In this paper, the relationship between Notch signaling pathway and mitochondrial energy metabolism is reviewed, in order to improve the understanding of them and provide new ideas for the treatment of related diseases.
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