记忆巩固
上瘾
海洛因
乙酰化
组蛋白
神经科学
心理学
启动(农业)
药理学
医学
药品
化学
生物
海马体
生物化学
基因
植物
发芽
作者
Jiaoqi Cheng,Binbin Wang,Hesuan Hu,Xin-Zhu Lin,Yuhang Liu,Lin Jin,Jinlong Zhang,Shuliang Niu,Jie Yan
标识
DOI:10.1016/j.biopha.2024.116414
摘要
Drug-associated long-term memories underlie substance use disorders, including heroin use disorder (HUD), which are difficult to eliminate through existing therapies. Addictive memories may become unstable when reexposed to drug-related cues and need to be stabilized again through protein resynthesis. Studies have shown the involvement of histone acetylation in the formation and reconsolidation of long-term drug-associated memory. However, it remains unknown whether and how histone acetyltransferases (HAT), the essential regulators of histone acetylation, contribute to the reconsolidation of heroin-associated memories. Herein, we investigated the function of HAT in the reconsolidation concerning heroin-conditioned memory by using a rat self-administration model. Systemic administration of the HAT inhibitor garcinol inhibited cue and heroin-priming induced reinstatement of heroin seeking, indicating the treatment potential of garcinol for relapse prevention.
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