Adaptive optical imaging with entangled photons

Adaptive optics (AO) has revolutionized imaging in fields from astronomy to microscopy by correcting optical aberrations. In label-free microscopes, however, conventional AO faces limitations because of the absence of a guide star and the need to select an optimization metric specific to the sample and imaging process. Here, we propose an AO approach leveraging correlations between entangled photons to directly correct the point spread function. This guide star–free method is independent of the specimen and imaging modality. We demonstrate the imaging of biological samples in the presence of aberrations using a bright-field imaging setup operating with a source of spatially entangled photon pairs. Our approach performs better than conventional AO in correcting specific aberrations, particularly those involving substantial defocus. Our work improves AO for label-free microscopy and could play a major role in the development of quantum microscopes.