Self-healing cellulose-based hydrogels: From molecular design to multifarious applications

Self-healing cellulose-based hydrogels (SHCHs) exhibit wide-ranging potential applications in the fields of biomedicine, environmental management, energy storage, and smart materials due to their unique physicochemical properties and biocompatibility. This review delves into the molecular design principles, performance characteristics, and diverse applications of SHCHs. Firstly, the molecular structure and physicochemical properties of cellulose are analyzed, along with strategies for achieving self-healing properties through molecular design, with particular emphasis on the importance of self-healing mechanisms. Subsequently, methods for optimizing the performance of SHCHs through chemical modification, composite reinforcement, stimulus responsiveness, and functional integration technologies are discussed in detail. Furthermore, applications of SHCHs in drug delivery, tissue engineering, wound healing, smart sensing, supercapacitors, electronic circuits, anti-counterfeiting systems, oil/water separation, and food packaging are explored. Finally, future research directions for SHCHs are outlined, including the innovative development of new SHCHs, in-depth elucidation of cooperative strengthening mechanisms, a further expansion of application scope, and the establishment of intelligent systems. This review provides researchers with a comprehensive overview of SHCHs and serves as a reference and guide for future research and development.