[ 225 Ac]Ac-Macropa-PEG 4 -HEA125 for Targeted α Therapy in Epithelial Cell Adhesion Molecule-Positive Tumors: Conjugation, Radiolabeling, and Efficacy

[²²⁵Ac]Ac-Macropa-PEG₄-HEA125, establishes high radiochemical purity, in vitro stability, EpCAM specificity, and strong antitumor activity in preclinical models. These results warrant its advancement as a promising targeted alpha therapy candidate for EpCAM-expressing carcinomas.