医学
2型糖尿病
初级保健
减肥
糖尿病
人口
不利影响
儿科
肥胖
内科学
物理疗法
家庭医学
内分泌学
环境卫生
作者
Samantha Hocking,Tania Markovic,Crystal Lee,Tegan Picone,Kate E Gudorf,Stephen Colagiuri
出处
期刊:Diabetes Care
[American Diabetes Association]
日期:2023-10-16
摘要
We aimed to assess whether remission of type 2 diabetes (T2D) could be achieved with a low-energy total diet replacement (TDR) in an Australian primary care setting.Individuals age 20 to 65 years with T2D duration up to 6 years, BMI >27.0 kg/m2 and not treated with insulin were prescribed a 13-week low-energy TDR (Optifast; Nestlé Health Science) followed by 8-week structured food reintroduction and 31-week supported weight maintenance. The primary outcome was T2D remission at 12 months.A total of 155 participants comprised the intention-to-treat population. At 12 months, T2D remission was achieved in 86 (56%) participants, with a mean adjusted weight loss of 8.1% (95% CI 7.2-9.1). Two serious adverse events requiring hospitalization related to the study intervention were reported.At 12 months T2D remission was achieved for one in two Australian adults in a primary care setting.
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