医学
骨关节炎
镜像
临床试验
疾病
物理疗法
重症监护医学
生物信息学
替代医学
内科学
病理
沟通
社会学
生物
作者
David T. Felson,Martin Lotz,Yuxuan Jin,Morgan Jones,Jason Kim,Kurt P. Spindler
标识
DOI:10.1136/ard-2023-224675
摘要
Animal models of post traumatic osteoarthritis have shown many promising treatments for disease, but human trials have mostly failed to identify effective treatments. This viewpoint suggests that the frequent failure of drug and treatment development in osteoarthritis is due, in part, to the advanced stage of disease of patients in trials and suggests that mirroring the animal model approach might be more successful. It suggests a path forward by enriching trial enrollees with those likely to develop post traumatic OA quickly.
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