Expression of cyclin D1 in parathyroid tumors and its clinical significance.

Objective:To investigate the expression of cyclin D1 in parathyroid tissues and its clinical significance. Methods:Immunohistochemical method was used to detect the expression of cyclin D1 in 3 parathyroid carcinoma tissues,8 parathyroid adenoma tissues,and 13 proliferative parathyroid tissues,1 parathyroid cyst,and 10 normal parathyroid tissues. Results:The overexpression ratio of cyclin D1 was significantly higher in parathyroid adenoma group and parathyroid carcinoma group than that in normal parathyroid group (P0.05). There was no significant difference between parathyroid proliferation group and parathyroid carcinoma group,or parathyroid adenoma group,or normal parathyroid group (P0.05). Conclusion:The overexpression of cyclin D1 played an important role in parathyroid adenoma and parathyroid carcinoma. Cyclin D1 might contribute to the etiology of parathyroid adenoma and carcinoma.