Molecular Pathogenesis of Primary Hyperparathyroidism

The molecular pathogenesis of primary hyperparathyroidism has recently been elucidated to a great extent, but many questions remain. While the molecular genetics of parathyroid disease have notable specific features, the general principles of parathyroid tumorigenesis are shared with those of tumor formation in other neoplastic diseases.KeywordsHyperparathyroidismCyclin D1MEN1CDKN1BCTNNB1p27B-CateninRETCASRHRPT2Parathyroid carcinomaParathyroid adenomaMultiple endocrine neoplasiaCalcium sensing receptorHyperparathyroidism jaw tumor syndromeFamilial isolated hyperparathyroidismParafibrominEctopic PTH secretionFHHNeonatal severe hyperparathyroidism