Bilateral renal agenesis (Potter's sequence) is usually a sporadic occurrence. Recurrence in the same family is rare. A family study of bilateral and unilateral renal agenesis was undertaken in three cases of renal agenesis in the same family. The grand-father and the father have a unilateral renal agenesis and his two stillborn infants had a Potter's syndrome. The author considered the familial nature of congenital absence of the kidneys and the relationship between hereditary bilateral renal agenesis and unilateral renal agenesis.