乳状液
医学
输送系统
经皮失水
活性成分
皮肤病科
皮肤护理
生物医学工程
角质层
药理学
化学
有机化学
病理
护理部
作者
Joseph Bikowski,Braham Shroot
出处
期刊:PubMed
日期:2007-03-22
卷期号:5 (10): 942-6
被引量:5
摘要
Multivesicular emulsion systems are a new patented technology for topical delivery of pharmaceutical and over-the-counter actives. This novel technology involves the creation of a 2-phase, oil-in-water emulsion system that produces concentric multilamellar spheres of oil and water. Active ingredients can be released from their respective layers upon application to the skin. In addition to a controlled-release of active agents, the multivesicular emulsion base improves the biophysical properties of the skin by reducing transepidermal water loss and enhancing skin hydration. This technology has been applied to 6% salicylic acid formulations that in clinical experience show efficacy with high tolerance in several hyperkeratotic disorders. Subjects' self-assessment was clearly indicative of the excellent cosmetic elegance of the multivesicular emulsion system.
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