The Prediction of The Risk for Hypertension in Carrier of Set of Alleles of Gene Encoding Methylene Tetrahydrofolate Reductase

Background MTHFR is a regulatory enzyme of homocysteine metabolism. The genetic polymorphism of the MTHFR gene has been reported to be associated with elevated plasma homocysteine in individual with low folic acid intake. Aim To investigate the influence of the C677T and A1298C polymorphisms of MTHFR gene on the development of hypertension together with the study of other metabolic risk factors for hypertension. Material& Method 66 normotensive individual and 60 hypertensive patients were enrolled in the study. The C677T and A1298C polymorphisms of MTHFR were identified by RFLP‐PCR of peripheral blood samples. Analysis of data was done by using SPSS program. Results Allele frequency for T allele of C677T polymorphism was higher in the hypertensive group compared to the normotensive group. The carriers of XT genotype (CT and TT) were at high risk of developing hypertension (OR= 1.8; 95% CI = 0.8–3.9) when compared with the carrier of CC genotype. Similarly carries of XC genotype (AC& CC) of A1298C were at high risk of developing hypertension (OR=1.5; 95%CI=0.6–4.1) when compared with AA genotype. The risk for hypertension was increased when the individual was carrier of both alleles (OR= 1.9; 95%CI= 0.6–5.8). Conclusion T and C allele of C677T and A1298C polymorphisms of MTHFR are possible genetic risk factors for hypertension. Source of Fund: Dubai Medical College