医学
类风湿性关节炎
脂肪酸代谢
月见草油
必需脂肪酸
γ-亚麻酸
全身性疾病
脂肪酸
内分泌学
新陈代谢
免疫学
内科学
免疫病理学
多不饱和脂肪酸
化学
生物化学
出处
期刊:PubMed
日期:1986-01-01
卷期号:61: 242-5
被引量:7
摘要
Evidence from biochemical studies and from experimental animals indicates that abnormalities of essential fatty acid (EFA) and eicosanoid metabolism could lead to salivary and lacrimal gland atrophy and to immunological and cardio-vascular defects. Measurements of EFA levels in erythrocytes from patients with primary Sjögren's syndrome have shown that abnormalities are indeed present. Controlled clinical trials of supplementation with gamma-linolenic acid (GLA) as evening primrose oil (Efamol) in both primary Sjögren's syndrome and systemic sclerosis have given positive results. There are strong arguments to indicate that sophisticated manipulation of EFA metabolism may have a role to play, not only in Sjögren's syndrome but also in other rheumatological disorders.
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