Video-rate Dual-modal Wide-beam Harmonic Ultrasound and Photoacoustic Computed Tomography

Dual-modal ultrasound (US) and photoacoustic (PA) imaging has tremendous advantages in biomedical applications, such as pharmacokinetics, cancer screening, and imaging-guided therapy. Compared with ring-shaped arrays, a linear piezoelectric transducer array applies to more anatomical sites and has been widely used in US/PA imaging. However, the linear array may limit the imaging quality due to narrow bandwidth, partial detection view, or sparse spatial sampling. To meet clinic demand of high-quality US/PA imaging with the linear transducer, we develop dual-modal wide-beam harmonic ultrasound (WBHUS) and photoacoustic computed tomography at video rate. The harmonic US imaging employs pulse phase inversion to reduce clutters and improve spatial resolution. Wide-beam US transmission can shorten the scanning times by 267% and enables a 20-Hz imaging rate, which can minimize motion artifacts in in vivo imaging. The harmonic US imaging does not only provide accurate anatomical references for locating PA features but also reduces artifacts in PA images. The improved image quality allows us to acquire high-resolution anatomical structures in deep tissue without labeling. The fast-imaging speed enables visualizing interventional procedures and monitoring the pulsations of the thoracic aorta and radial artery in real-time. The video-rate dual-modal harmonic US and single-shot PA computed tomography use a clinical-grade linear-array transducer and thus can be readily implemented in clinical US imaging.