免疫系统
背景(考古学)
树突状细胞
生物
抗原
细胞生物学
免疫学
功能(生物学)
平衡
表型
淋巴结
遗传学
基因
古生物学
作者
Sofie Hedlund Møller,Limei Wang,Ping‐Chih Ho
标识
DOI:10.1038/s41423-021-00753-1
摘要
It is being increasingly acknowledged that immune cells depend on certain metabolic traits to perform their functions and that the extracellular environment can influence cell metabolism and vice versa. Dendritic cell (DC) subsets traffic through highly diverse environments from the bone marrow, where they develop, to the various peripheral tissues, where they differentiate and capture antigens, before they migrate to the lymph node to present antigens and prime T cells. It is plausible that DC subsets modulate their stimulatory abilities in response to unique metabolic programming. The metabolic requirements of DCs are just recently being discovered, and subset- and context-specific metabolic phenotypes in DCs are highly intertwined with DC functions. In this review, we present the current knowledge on the intrinsic and extrinsic determinants of DC metabolism, how they regulate DC function with examples from tumor biology and in interaction with the microbiota, and discuss how this can be applied therapeutically.
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