海马结构
高渗盐水
口渴
海马体
音调
内分泌学
内科学
取水口
电生理学
体内
神经科学
生理盐水
锥体细胞
化学
生物
医学
生物技术
作者
Bingxuan Han,Shuang Cui,Fengyu Liu,You Wan,Yan Shi,Ming Yi
出处
期刊:American Journal of Physiology-cell Physiology
[American Physiological Society]
日期:2021-12-01
卷期号:321 (6): C992-C999
被引量:1
标识
DOI:10.1152/ajpcell.00211.2021
摘要
Thirst is an important interoceptive response and drives water consumption. The hippocampus actively modulates food intake and energy metabolism, but direct evidence for the exact role of the hippocampus in modulating drinking behaviors is lacking. We observed decreased number of c-Fos-positive neurons in the ventral hippocampal CA1 (vCA1) after water restriction or hypertonic saline injection in rats. Suppressed vCA1 neuronal activities under the hypertonic state were further confirmed with in vivo electrophysiological recording, and the level of suppression paralleled both the duration and the total amount of water consumption. Chemogenetic inhibition of vCA1 pyramidal neurons increased water consumption in rats injected with both normal and hypertonic saline. These findings suggest that suppression of vCA1 pyramidal neuronal activities enhances water intake.
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