抗生素
金黄色葡萄球菌
耐甲氧西林金黄色葡萄球菌
医学
多重耐药
氨基糖苷
重症监护医学
微生物学
生物
细菌
遗传学
作者
Chengjiao Yao,Yilin Li,Mengjun Pu,Lihong Luo,Qin Xiong,Fengjiao Xie,Tinglin Li,Peimin Feng
标识
DOI:10.2174/1568026621666211004093647
摘要
Methicillin-resistant Staphylococcus aureus (MRSA), a leading cause of infections in human being and is usually associated with a multidrug-resistant profile, represents a significant health threat and public burden globally. The limited options of effective antibiotics motivate the search for novel anti-MRSA agents. Aminoglycoside antibiotics have been extensively applied in the medical field due to their desirable broad-spectrum antibacterial activity, especially for systemic infections caused by Gram-negative organisms. Recent studies demonstrated that aminoglycosides also possessed potential activity against MRSA, so aminoglycosides may be useful weapons to fight against MRSA. The present work aims to summarize the current scenario of aminoglycosides with anti- MRSA potential, covering articles published between 2010 and 2020. The structure-activity relationship and the mechanism of action are also discussed for the further rational design of novel potential drug candidates.
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