急性呼吸窘迫综合征
药理学
医学
儿茶素
信号转导
炎症
TLR4型
肺
脂多糖
免疫学
化学
生物化学
内科学
多酚
抗氧化剂
作者
Yong Zhao,Hao Zheng,Shengnan Yang,Xiaoqing Zhang,Wei Dong,Yu Shi,Yuechuan Li,Jing Feng
标识
DOI:10.1080/08923973.2021.2002890
摘要
Acute lung injury (ALI) and resultant acute respiratory distress syndrome (ARDS) are detrimental inflammatory disease associated with high rates of morbidity and mortality due to a lack of effective treatment options. Previous study has demonstrated that an inhibition of geranylgeranyl pyrophosphate synthase large subunit 1 (GGPPS1) show a protective effect against ALI.In this study, by using connective map (CMAP), we identified catechin as a potential drug to exhibit similar effects to inhibit GGPPS1. Furthermore, we detected the protective effect of catechin on lipopolysaccharide (LPS)-induced ALI and delineated the underlying mechanism.We found that catechin effectively ameliorated LPS-induced lung inflammation and alleviated the release of cytokines into alveolar space. Notably, miR-182/GGPPS1 signaling pathway was reactivated upon catechin administration, which was essential for the catechin-induced protective effect against ALI.catechin regulates miR-182/GGPPS1 signaling pathway and efficaciously ameliorates LPS-induced acute lung injury in mice model, which provided a promising therapeutic strategy in ALI and ARDS.
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