FAPI Uptake in a Vertebral Body Fracture in a Patient With Lung Cancer

Abstract A left pulmonary nodule was identified by CT scan in a 53-year-old woman who had a car accident 10 days earlier. 18 F-FDG PET/CT showed multiple FDG-avid lesions located at the left lung nodule, mediastinal lymph nodules, and L4 vertebral body. 68 Ga-FAPI PET/CT was performed for further evaluation. However, 68 Ga-FAPI demonstrated intense FAPI uptake in the accident-related fracture of the L4 vertebral body. This case documents that the fracture of the vertebral body may cause FAPI uptake, and nuclear clinicians evaluating 68 Ga-FAPI imaging should be aware of this potential pitfall.