叶立德
化学
重氮
分子内力
卡宾
碳化物
催化作用
表面改性
组合化学
立体化学
药物化学
有机化学
铑
物理化学
作者
Anil Kumar,Mahadev Sharanappa Sherikar,Vinayak Hanchate,Kandikere Ramaiah Prabhu
出处
期刊:Tetrahedron
[Elsevier]
日期:2021-11-01
卷期号:101: 132478-132478
被引量:45
标识
DOI:10.1016/j.tet.2021.132478
摘要
Sulfoxonium ylides are carbene precursors and safer alternatives for highly reactive and unstable diazo compounds, and they are used extensively in the field of C-H activation. The current review is a collection of recent advancements in transition-metal-catalyzed C(sp2)-H activation using sulfoxonium ylides as precursors. The review emphasizes the use of sulfoxonium ylides as coupling partners for acylmethylation of arenes and heteroarenes. Also, it accounts for the construction of heterocycles employing sulfoxonium ylide as a coupling partner with non-innocent directing groups by C-H activation, acylmethylation followed by intramolecular cyclization in one pot or domino fashion. The review also highlights recent advances in C-H activation reactions using sulfoxonium ylide as a carbenoid-based directing group to construct carbocyclic rings. The review focuses on using sulfoxonium ylide as a coupling partner and directing group, followed by the mode of transformation, scope of the reaction, and the possible mechanistic aspect.
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