Tumor suppressive effect of anti-PD-1 antibody against angiosarcoma in a mouse model

Programmed cell death protein 1 (PD-1) and its ligand, programmed cell death protein 1- ligand 1 (PD-L1), known as the immune checkpoints, negatively regulate T-cell-mediated immune responses and promote tumor immune escape. Recently, PD-1/PD-L1 antibodies (Abs) has been proved to be effective for various cancer types [ [1] Postow M.A. Callahan M.K. Wolchok J.D. Immune checkpoint blockade in cancer therapy. J. Clin. Oncol. 2015; 33: 1974-1982 Crossref PubMed Scopus (1542) Google Scholar ].