体外循环
硝酸盐
医学
心脏外科
材料科学
体外循环
作者
Yu Qin,Joanna Zajda,Elizabeth J. Brisbois,Hang Ren,John M. Toomasian,Terry C. Major,Alvaro Rojas-Pena,Benjamin D. Carr,Thomas M. Johnson,Jonathan W. Haft,Robert H. Bartlett,Andrew P. Hunt,Nicolai Lehnert,Mark E. Meyerhoff
标识
DOI:10.1021/acs.molpharmaceut.7b00514
摘要
A new portable gas phase nitric oxide (NO) generator is described for potential applications in inhaled NO (INO) therapy and during cardiopulmonary bypass (CPB) surgery. In this system, NO is produced at the surface of a large-area mesh working electrode by electrochemical reduction of nitrite ions in the presence of a soluble copper(II)-ligand electron transfer mediator complex. The NO generated is then transported into gas phase by either direct purging with nitrogen/air or via circulating the electrolyte/nitrite solution through a gas extraction silicone fiber-based membrane-dialyzer assembly. Gas phase NO concentrations can be tuned in the range of 5–1000 ppm (parts per million by volume for gaseous species), in proportion to a constant cathodic current applied between the working and counter electrodes. This new NO generation process has the advantages of rapid production times (5 min to steady-state), high Faraday NO production efficiency (ca. 93%), excellent stability, and very low cost when using ...
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