Objective To study the effect and safety of tiotropium bromide inhalation combined with formoterol inhalation on chronic obstructive pulmonary disease(COPD).Methods46 COPD patients were randomly divided into 2 groups.Treatment group was treated with tiotropium bromide + formoterol;control group was treated with formoterol.The course was 4 weeks.The symptoms and lung function were observed before and after treatment.ResultsThere were significant differences in the symptoms and FEV1 between 2 groups(P0.05).No significant adverse reaction was found.ConclusionThe therapeutic effect of tiotropium bromide inhalation and formoterol inhalation on COPD is better than that of tiotropium.