老化
医学
动脉硬化
临床实习
血管疾病
疾病
健康老龄化
病理生理学
内科学
重症监护医学
心脏病学
外科
血压
物理疗法
作者
Pedro Cunha,Pierre Boutouyrie,Peter M. Nilsson,Stéphane Laurent
出处
期刊:Current Hypertension Reviews
[Bentham Science]
日期:2017-06-19
卷期号:13 (1)
被引量:81
标识
DOI:10.2174/1573402113666170413094319
摘要
Arterial stiffness has been accumulating evidence as an intermediate cardiovascular endpoint. It has been established as an independent risk marker for cardiovascular disease, and reflects the dissociation between chronologic and biologic age of large arteries-attributing earlier the risk that a normal vascular ageing process had installed to occur several years later. The concept of Early Vascular Ageing (EVA) is developed to establish primordial prevention, identifying individuals whose ageing path has been accelerated either by inherent features, interaction with the environment or arterial exposure to several types of insults that evolve to medial layer morphological changes. Understanding the pathophysiology of vascular ageing, its consequences and therapeutic opportunities is therefore an advantage that could be translated in time of prevention and survival free of cardiovascular disease. As the EVA construct is advancing, new features appear as interesting to better translate it into clinical practice.
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