自噬
自噬体
细胞生物学
可药性
免疫系统
生物
疾病
平衡
粒体自噬
医学
免疫学
生物化学
细胞凋亡
基因
内科学
作者
Étienne Morel,Maryam Mehrpour,Joëlle Botti,Nicolas Dupont,Ahmed Hamaï,Anna Chiara Nascimbeni,Patrice Codogno
出处
期刊:Annual Review of Pharmacology and Toxicology
[Annual Reviews]
日期:2017-01-06
卷期号:57 (1): 375-398
被引量:125
标识
DOI:10.1146/annurev-pharmtox-010716-104936
摘要
Macroautophagy (hereafter called autophagy) is a vacuolar, lysosomal pathway for catabolism of intracellular material that is conserved among eukaryotic cells. Autophagy plays a crucial role in tissue homeostasis, adaptation to stress situations, immune responses, and the regulation of the inflammatory response. Blockade or uncontrolled activation of autophagy is associated with cancer, diabetes, obesity, cardiovascular disease, neurodegenerative disease, autoimmune disease, infection, and chronic inflammatory disease. During the past decade, researchers have made major progress in understanding the three levels of regulation of autophagy in mammalian cells: signaling, autophagosome formation, and autophagosome maturation and lysosomal degradation. As we discuss in this review, each of these levels is potentially druggable, and, depending on the indication, may be able to stimulate or inhibit autophagy. We also summarize the different modulators of autophagy and their potential and limitations in the treatment of life-threatening diseases.
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