PS 08-14 THE INFLUENCE OF LOSARTAN TO SERUM ASYMMETRIC DIMETHYLARGININE (ADMA) LEVEL IN HYPERTENSION PATIENT WITH ASYMPTOMATIS HYPERURICEMIA IN RSMH PALEMBANG

Objective: To determine the influence of losartan on reduction of serum ADMA levels in hypertension patients with asymptomatic hyperuricemia. Design and Method: The design of this study is a clinical trial before and after, which is done in general and consult policlinic, Internal Medicine Department at RSMH Palembang from May to August 2013. A total of 30 patients with stage 1 hypertension and hyperuricemia was given 50 mg losartan drug once daily for 8 weeks. Before therapy was started, blood pressure, serum uric acid, 24-hour urine uric acid and serum ADMA were measured and repeated after 8 weeks. Blood pressure was measured every 2 weeks. Results: The mean serum ADMA levels prior to administration of losartan was 0.74 μmol / l. The mean ADMA levels after the administration of losartan was 0.56 μmol / l. There was a decrease in mean serum ADMA levels after the administration of losartan. The results were statistically significant on reduction of serum ADMA levels after the administration of losartan with p = 0.001. Conclusions: There is an influence of losartan on reduction of serum ADMA levels in hypertension patients with asymptomatic hyperuricemia, and the differences were statistically significant with p = 0.001.