河马信号通路
效应器
转录因子
生物
细胞生物学
癌变
转录调控
抄写(语言学)
背景(考古学)
癌症研究
遗传学
癌症
基因
语言学
哲学
古生物学
作者
Yibo Guo,Juan Luo,Hailin Zou,Chenxin Liu,Liang Deng,Peng Li
标识
DOI:10.1016/j.canlet.2021.12.019
摘要
As the downstream effectors of Hippo pathway, YAP/TAZ are identified to participate in organ growth, regeneration and tumorigenesis. However, owing to lack of a DNA-binding domain, YAP/TAZ usually act as coactivators and cooperate with other transcription factors or partners to mediate their transcriptional outputs. In this article, we first present an overview of the core components and the upstream regulators of Hippo-YAP/TAZ signaling in mammals, and then systematically summarize the identified transcription factors or partners that are responsible for the downstream transcriptional output of YAP/TAZ in various cancers.
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