化学
黄酮类
去甲基化
催化作用
区域选择性
分子内力
硫醇
组合化学
基础(拓扑)
有机化学
立体化学
色谱法
生物化学
基因表达
DNA甲基化
基因
数学分析
数学
作者
Ritiele Heck,Thiago Ribeiro,Maira Regina Giehl,Ricardo F. Schumacher,Benhur Godoi
出处
期刊:Synthesis
[Georg Thieme Verlag KG]
日期:2022-06-13
卷期号:54 (20): 4601-4607
被引量:2
摘要
Abstract Flavone and analogues represent an important class of biologically and pharmacologically active substances commonly found in the composition of diverse plants as part of the class of secondary metabolites. Herein, an efficient and regioselective synthetic strategy for the preparation of functionalized flavones is demonstrated through sequential demethylation/6-endo-dig intramolecular cyclization of propyn-1-ones, using catalytic amounts of base in the presence of a thiol, by employing NMP as the solvent. The reactions proceeded smoothly under transition-metal-free and open to air conditions, furnishing the desired six-membered heterocycles in moderate to excellent yields, in short reaction time.
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