对映选择合成
部分
分子内力
化学
磷酸
戒指(化学)
组合化学
立体化学
平面的
平面手性
催化作用
有机化学
计算机科学
计算机图形学(图像)
作者
Shaoze Yu,Guosong Shen,Faqian He,Xiaoyu Yang
摘要
A novel enantioselective macrocyclization method has been developed for the asymmetric synthesis of planar-chiral macrocycles through chiral phosphoric acid-catalyzed intramolecular addition of the hydroxy group with the allenamide moiety. A series of planar-chiral macrocycles bearing various ring sizes (18-member to 22-member) and various functional groups were generated with good to high enantioselectivities.
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