There is a limited understanding of IT's role as a crucial enabler of patient\nagility and the department's ability to respond to patient's needs and wishes\nadequately. This study's objective is to contribute to the insights of the\nvalidity of the hypothesized relationship between IT resources, practices and\ncapabilities, and hospital departments' knowledge processes and the\ndepartment's ability to adequately sense and respond to patient needs and\nwishes, i.e., patient agility. This study conveniently sampled data from 107\nclinical hospital departments in the Netherlands and uses structural equation\nmodeling for model assessment. IT ambidexterity positively enhances the\ndevelopment of a digital dynamic capability. Likewise, IT ambidexterity also\npositively impacts the hospital department's knowledge processes. Both digital\ndynamic capability and knowledge processes positively influence patient\nagility. IT ambidexterity promotes taking advantage of IT resources and\nexperiments to reshape patient services and enhance patient agility.\n