Hypoglycemic effect of the polysaccharides fromAstragalus membranaceuson type 2 diabetic mice based on the “gut microbiota–mucosal barrier”

by 11.72% and 30.70%, respectively. In addition, the antibiotic test indicated that the APP could repair intestinal barrier damage by remodeling some specific gut microbiota which may be their hypoglycemic mechanism. The results provide a theoretical basis for the development of APP as a novel prebiotic in functional food for diabetes.