Differential right ventricular afterload during exercise in idiopathic pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension

This study is the first to characterize exercise-induced changes in the PVR-PAC relationship in IPAH and CTEPH. Despite similar PVR, patients with CTEPH showed significantly lower PAC and RC time constant at rest and during exercise. A leftward shift in the inverse PVR-PAC relationship in CTEPH highlights the importance of assessing both PAC and PVR under stress for accurate clinical assessment and tailored management for each subtype of PH.