Application of metal–organic framework-based reactive oxygen species therapy in cancer

Reactive oxygen species (ROS) hold significant therapeutic potential in cancer treatment, with metal-organic framework (MOF)-based nanocarriers showing considerable promise for ROS-mediated therapies. This review systematically explores the advantages of MOFs in cancer treatment, focusing on their synthesis, structure, and biological applications. It further focuses on the efficacy of MOFs in ROS therapy, emphasizing their role in modulating the tumor microenvironment through Fenton/Fenton-like reactions and enzyme-like activity. Notably, the review also addresses the application and potential synergistic mechanisms of MOF-based ROS therapies in combination and synergistic cancer treatments. Finally, innovative MOF-based ROS combination therapies in anticancer applications are discussed, highlighting the enhanced therapeutic effects of MOF-augmented ROS and their potential for synergistic treatment strategies. In summary, this review provides an important reference for promoting the development of ROS-based anticancer nanomedicines and accelerating biomedical technology innovation.