拉诺司坦
立体化学
化学
三萜类
生物
植物
三萜
医学
病理
替代医学
作者
Ru-Feng Xia,Jun-Cheng Su,Yuanyuan Wang,Hong-Jing Zha,Jiale Wu,Xiao-Na Fu,Qing Cai,Luo-Sheng Wan
出处
期刊:Phytochemistry
[Elsevier]
日期:2023-07-01
卷期号:211: 113682-113682
被引量:1
标识
DOI:10.1016/j.phytochem.2023.113682
摘要
Phytochemical investigations on the ethanol extract of the whole plant of Euphorbia maculata Linn. Resulted in the identification of 16 lanostane-related triterpenoids, including 11 undescribed ones, namely spiromaculatols A-C (1-3) and euphomaculatoids A-H (4-11). The structural determinations of the previously undescribed ones (1-11) were elucidated based on the interpretation of comprehensive spectroscopic data, quantum chemical calculation, as well as X-ray crystallographic experiments. Spiromaculatols A-C (1-3) possess a rare spirobi [indane] skeleton, which was biosynthetically derived from the 7 (8 → 9)-abeo bond migration of lanostane precursors. The biological activity of compounds 1-3, 5, 7, and 12-13 displayed inhibitory effect on the release of NO in an LPS-activated RAW264.7 cells model. Molecular mechanism study indicated that the most potent spiromaculatol C (3) can reduce the nuclear translocation of NF-κB p65 and decrease the transcriptional expressions of its downstream pro-inflammatory mediators.
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