Synthesis of Stylissamide B, a Pro‐Rich Cyclic Heptapeptide Isolated From the Marine Sponge Stylissa caribica

ABSTRACT Stylissamide B was successfully synthesized for the first time using Fmoc solid‐phase peptide synthesis (Fmoc‐SPPS) followed by cyclization in solution phase. The Fmoc‐SPPS process was monitored using the reversible detection method for amino groups (ReD‐A method). The linear peptide, Pro‐Pro‐Ile‐Tyr‐Pro‐Phe‐Pro, was cyclized to form stylissamide B. The spectral data obtained were in agreement with previously reported literature, thereby confirming the reliability of the synthetic method.