衰老
生物
再生(生物学)
肝再生
细胞衰老
癌症研究
细胞模型
纤维化
机制(生物学)
细胞生物学
生物信息学
病理
医学
细胞培养
表型
遗传学
哲学
认识论
基因
作者
Ting Ge,Yunyun Shao,Xiaofeng Bao,Chunfeng Lu,Chunfeng Lu
标识
DOI:10.1016/j.intimp.2023.110522
摘要
Cellular senescence is an irreversible state of cell cycle arrest, characterized by a gradual decline in cell proliferation, differentiation, and biological functions. Cellular senescence is double-edged for that it can provoke organ repair and regeneration in physiological conditions but contribute to organ and tissue dysfunction and prime multiple chronic diseases in pathological conditions. The liver has a strong regenerative capacity, where cellular senescence and regeneration are closely involved. Herein, this review firstly introduces the morphological manifestations of senescent cells, the major regulators (p53, p21, and p16), and the core pathophysiologic mechanisms underlying senescence process, and then specifically generalizes the role and interventions of cellular senescence in multiple liver diseases, including alcoholic liver disease, nonalcoholic fatty liver disease, liver fibrosis, and hepatocellular carcinoma. In conclusion, this review focuses on interpreting the importance of cellular senescence in liver diseases and summarizes potential senescence-related regulatory targets, aiming to provide new insights for further researches on cellular senescence regulation and therapeutic developments for liver diseases.
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