酶
化学
过氧化物酶
纳米技术
组合化学
催化作用
过氧化氢酶
材料科学
生物化学
作者
Bo Yuan,Zicong Tan,Qiang Guo,Xuefeng Shen,Chao Zhao,Jian Lin Chen,Yung‐Kang Peng
出处
期刊:ACS Nano
[American Chemical Society]
日期:2023-08-14
卷期号:17 (17): 17383-17393
被引量:9
标识
DOI:10.1021/acsnano.3c05409
摘要
Nanozymes are promising alternatives to natural enzymes, but their use remains limited owing to poor specificity. For example, CeO2 activates H2O2 and displays peroxidase (POD)-like, catalase (CAT)-like, and haloperoxidase (HPO)-like activities. Since they unavoidably compete for H2O2, affecting its utilization in the target application, the precise manipulation of reaction specificity is thus imperative. Herein, we showed that one can simply achieve this by manipulating the H2O2 activation pathway on pristine CeO2 in well-defined shapes. This is because the coordination and electronic structures of Ce sites vary with CeO2 surfaces, wherein the (100) and (111) surfaces display nearly 100% specificity toward POD-/CAT-like and HPO-like activities, respectively. The antibacterial results suggest that the latter surface can well-utilize H2O2 to kill bacteria (cf., the former), which is promising for anti-biofouling applications. This work provides atomic insights into the synthesis of nanozymes with improved activity, reaction specificity, and H2O2 utilization.
科研通智能强力驱动
Strongly Powered by AbleSci AI