医学
炎症体
内科学
内分泌学
纤维化
血压
心肌纤维化
自发性高血压大鼠
血管紧张素II
受体
肾素-血管紧张素系统
作者
Na Liu,Zhaowei Gong,Li Yang,Yang Xu,Yutong Guo,Wen-Jia Chen,Xue Sun,Xinhua Yin,Wenxiu Liu
标识
DOI:10.1097/hjh.0000000000003591
摘要
CTRP3 expression was decreased in the myocardium of SHR rats, and exogenous CTRP3 inhibited Ang II-induced fibrosis in cardiac fibroblasts by regulating the P2X7R-NLRP3 inflammasome pathway, suggesting that CTRP3 is a potential drug for alleviating myocardial fibrosis in hypertensive conditions.
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